Osteoarthritis (OA) is the most common type of arthritis, a disease that affects the entire joint.
The relative involvement of each tissue, and their interactions, add to the complexity of OA,
hampering our understanding of the underlying molecular mechanisms, and the generation
of a disease modifying therapy. The synovium is essential in maintaining joint homeostasis,
and pathologies associated with the synovium contribute to joint destruction, pain and
stiffness in OA. MicroRNAs (miRNAs) are post-transcriptional regulators dysregulated in OA …