In many leukemia patients, a poor prognosis is attributed either to the development of
chemotherapy resistance by leukemic stem cells (LSCs) or to the inefficient engraftment of
transplanted hematopoietic stem/progenitor cells (HSPCs) into the bone marrow (BM). Here,
we build a 3D in vitro model system of bone marrow organoids (BMOs) that recapitulate
several structural and cellular components of native BM. These organoids are formed in a
high-throughput manner from the aggregation of endothelial and mesenchymal cells within …