Bead-based technologies are an attractive alternative to classical microarrays due to the
high surface area of the beads which enables the immobilization of large numbers of probe
molecules leading to increased kinetics and improved signal/noise ratios. A simple, versatile
and inexpensive method for the fabrication of magnetic bead arrays is presented. The beads
are first assembled into silicon pyramidal wells that have been fabricated by established
microfabrication techniques and then mounted onto the apex of PDMS pyramids that …