Traumatic spinal cord injury (SCI) triggers a neuro-inflammatory response dominated by
tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated
microglia and MDMs are morphologically identical and express similar phenotypic markers
in vivo, identifying injury responses specifically coordinated by microglia has historically
been challenging. Here, we pharmacologically depleted microglia and use anatomical,
histopathological, tract tracing, bulk and single cell RNA sequencing to reveal the cellular …