Recent studies by our group and others show that microRNAs can be actively secreted into
the extracellular environment through microvesicles (MVs) and function as secretory
signaling molecules that influence the recipient cell phenotypes. Here we investigate the
role of monocyte-secreted miR-150 in promoting the capillary tube formation of endothelial
cells and in enhancing angiogenesis. In vitro capillary tube formation and in vivo
angiogenesis assays showed that monocyte-derived MVs have strong pro-angiogenic …