Microwave irradiated one pot, three component synthesis of a new series of hybrid coumarin based thiazoles: Antibacterial evaluation and molecular docking studies
A series of new coumarin based thiazoles were synthesized by the microwave irradiation of
thiocarbohydrazide, aldehydes and 3-(2-bromoacetyl) coumarins. Structures of all the
synthesized compounds were confirmed by spectral (1 H & 13 C NMR, FTIR, Mass) and
analytical data. The target compounds were screened for their in vitro cytotoxic activity
against a Gram positive spheroid firmicute. From the in vitro results, it was found that the
compound 4e has bordering on activity with the standard. Furthermore docking studies were …
thiocarbohydrazide, aldehydes and 3-(2-bromoacetyl) coumarins. Structures of all the
synthesized compounds were confirmed by spectral (1 H & 13 C NMR, FTIR, Mass) and
analytical data. The target compounds were screened for their in vitro cytotoxic activity
against a Gram positive spheroid firmicute. From the in vitro results, it was found that the
compound 4e has bordering on activity with the standard. Furthermore docking studies were …
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