Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology
D Baglietto-Vargas, R Medeiros, H Martinez-Coria… - Biological …, 2013 - Elsevier
Background Increased circulating glucocorticoids are features of both aging and Alzheimer's
disease (AD), and increased glucocorticoids accelerate the accumulation of AD pathologies.
Here, we analyzed the effects of the glucocorticoid receptor antagonist mifepristone (RU486)
in the 3xTg-AD mouse model at an age where hippocampal damage leads to high
circulating corticosterone levels. Methods The effects of mifepristone were investigated in
3xTg-AD mice using a combination of biochemical, histological, and behavior analyses …
disease (AD), and increased glucocorticoids accelerate the accumulation of AD pathologies.
Here, we analyzed the effects of the glucocorticoid receptor antagonist mifepristone (RU486)
in the 3xTg-AD mouse model at an age where hippocampal damage leads to high
circulating corticosterone levels. Methods The effects of mifepristone were investigated in
3xTg-AD mice using a combination of biochemical, histological, and behavior analyses …
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