Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response
R Filograna, S Lee, K Tiklova, M Mennuni… - PLoS …, 2021 - journals.plos.org
Dopamine (DA) neurons of the midbrain are at risk to become affected by mitochondrial
damage over time and mitochondrial defects have been frequently reported in Parkinson's
disease (PD) patients. However, the causal contribution of adult-onset mitochondrial
dysfunction to PD remains uncertain. Here, we developed a mouse model lacking Mitofusin
2 (MFN2), a key regulator of mitochondrial network homeostasis, in adult midbrain DA
neurons. The knockout mice develop severe and progressive DA neuron-specific …
damage over time and mitochondrial defects have been frequently reported in Parkinson's
disease (PD) patients. However, the causal contribution of adult-onset mitochondrial
dysfunction to PD remains uncertain. Here, we developed a mouse model lacking Mitofusin
2 (MFN2), a key regulator of mitochondrial network homeostasis, in adult midbrain DA
neurons. The knockout mice develop severe and progressive DA neuron-specific …
[PDF][PDF] Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune
K Tiklová - 2021 - research.chalmers.se
Dopamine (DA) neurons of the midbrain are at risk to become affected by mitochondrial
damage over time and mitochondrial defects have been frequently reported in Parkinson's
disease (PD) patients. However, the causal contribution of adult-onset mitochondrial
dysfunction to PD remains uncertain. Here, we developed a mouse model lacking Mitofusin
2 (MFN2), a key regulator of mitochondrial network homeostasis, in adult midbrain DA
neurons. The knockout mice develop severe and progressive DA neuron-specific …
damage over time and mitochondrial defects have been frequently reported in Parkinson's
disease (PD) patients. However, the causal contribution of adult-onset mitochondrial
dysfunction to PD remains uncertain. Here, we developed a mouse model lacking Mitofusin
2 (MFN2), a key regulator of mitochondrial network homeostasis, in adult midbrain DA
neurons. The knockout mice develop severe and progressive DA neuron-specific …