Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia
Critical limb ischemia is a devastating manifestation of peripheral arterial disease with no
effective strategies for improving morbidity and mortality outcomes. We tested the hypothesis
that cellular mitochondrial function is a key component of limb pathology and that improving
mitochondrial function represents a novel paradigm for therapy. BALB/c mice were treated
with a therapeutic mitochondrial-targeting peptide (MTP-131) and subjected to limb
ischemia (HLI). Compared to vehicle control, MTP-131 rescued limb muscle capillary density …
effective strategies for improving morbidity and mortality outcomes. We tested the hypothesis
that cellular mitochondrial function is a key component of limb pathology and that improving
mitochondrial function represents a novel paradigm for therapy. BALB/c mice were treated
with a therapeutic mitochondrial-targeting peptide (MTP-131) and subjected to limb
ischemia (HLI). Compared to vehicle control, MTP-131 rescued limb muscle capillary density …
[PDF][PDF] Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia
J McClung, TE Ryan, CA Schmidt, RJ Alleman… - 2016 - thescholarship.ecu.edu
Critical limb ischemia is a devastating manifestation of peripheral arterial disease with no
effective strategies for improving morbidity and mortality outcomes. We tested the hypothesis
that cellular mitochondrial function is a key component of limb pathology and that improving
mitochondrial function represents a novel paradigm for therapy. BALB/c mice were treated
with a therapeutic mitochondrial-targeting peptide (MTP-131) and subjected to limb
ischemia (HLI). Compared to vehicle control, MTP-131 rescued limb muscle capillary density …
effective strategies for improving morbidity and mortality outcomes. We tested the hypothesis
that cellular mitochondrial function is a key component of limb pathology and that improving
mitochondrial function represents a novel paradigm for therapy. BALB/c mice were treated
with a therapeutic mitochondrial-targeting peptide (MTP-131) and subjected to limb
ischemia (HLI). Compared to vehicle control, MTP-131 rescued limb muscle capillary density …
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