Leveraging the potential of digital twins is of utmost importance to support smart production. Digital twin research has principally focused on defining digital twin concepts and applications and proposing various frameworks for their implementation. Less is known about using simplified models to overcome many challenges related to digital twin models. Based on a longitudinal case study at a multinational manufacturing company engaged in digital twins in manufacturing efforts, this paper identifies the main challenges encountered related to people, processes, and technology, as well as requirements placed on a digital twin. This study also presents the opportunities of applying simplified models for digital twins to overcome the identified challenges and fulfill the defined requirements. The present study provides theoretical and practical implications of the development of digital twins in manufacturing, focusing attention on the challenges and requirements that affect the outcome of the manufacturing company to drive digital twin efforts.