Human telencephalon is an evolutionarily advanced brain structure associated with many
uniquely human behaviors and disorders. However, cell lineages and molecular pathways
implicated in human telencephalic development remain largely unknown. We produce
human telencephalic organoids from stem cell-derived single neural rosettes and
investigate telencephalic development under normal and pathological conditions. We show
that single neural rosette-derived organoids contain pallial and subpallial neural …