Taking over vehicle control from a Level 3 conditionally automated vehicle can be a demanding task for a driver. The take-over determines the controllability of automated vehicle functions and thereby also traffic safety. This paper presents models predicting the main take-over performance variables take-over time, minimum time-to-collision, brake application and crash probability. These variables are considered in relation to the situational and driver-related factors time-budget, traffic density, non-driving-related task, repetition, the current lane and driver’s age. Regression models were developed using 753 take-over situations recorded in a series of driving simulator experiments. The models were validated with data from five other driving simulator experiments of mostly unrelated authors with another 729 take-over situations. The models accurately captured take-over time, time-to-collision and crash probability, and moderately predicted the brake application. Especially the time-budget, traffic density and the repetition strongly influenced the take-over performance, while the non-driving-related tasks, the lane and drivers’ age explained a minor portion of the variance in the take-over performances.