Modulation of DNA fragmentation factor 40 nuclease activity by poly (ADP-ribose) polymerase-1
JD West, C Ji, LJ Marnett - Journal of Biological Chemistry, 2005 - ASBMB
Poly (ADP-ribose) polymerase-1 (PARP-1) influences numerous cellular processes,
including DNA repair, transcriptional regulation, and caspase-independent cell death, by
utilizing NAD+ to synthesize long chains of poly (ADP-ribose)(PAR) on target proteins,
including itself. During the apoptotic response, caspases-3 and-7 cleave PARP-1, thereby
inhibiting its activity. Here, we have examined the role of PARP-1 activation and cleavage in
the latter stages of apoptosis in response to DNA fragmentation. PARP-1 poly (ADP-ribosyl) …
including DNA repair, transcriptional regulation, and caspase-independent cell death, by
utilizing NAD+ to synthesize long chains of poly (ADP-ribose)(PAR) on target proteins,
including itself. During the apoptotic response, caspases-3 and-7 cleave PARP-1, thereby
inhibiting its activity. Here, we have examined the role of PARP-1 activation and cleavage in
the latter stages of apoptosis in response to DNA fragmentation. PARP-1 poly (ADP-ribosyl) …
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