[HTML][HTML] Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis
M Qiu, K Huang, Y Liu, Y Yang, H Tang, X Liu… - Mucosal …, 2019 - Elsevier
High-fat diet (HFD) promotes lung pre-metastatic niche formation and metastasis. Thus,
there is an urgent need to identify the underlying mechanisms and develop strategies to
overcome them. Here we demonstrate that glycyrrhizic acid (GA) prevents HFD-enhanced
pre-metastatic niche formation and metastasis through gut microbiota. GA reduced HFD-
enhanced myeloid-derived suppressor cell recruitment, pro-metastatic protein S100A8/A9
expression and metastasis burden of 4T1 breast cancer and B16F10 melanoma …
there is an urgent need to identify the underlying mechanisms and develop strategies to
overcome them. Here we demonstrate that glycyrrhizic acid (GA) prevents HFD-enhanced
pre-metastatic niche formation and metastasis through gut microbiota. GA reduced HFD-
enhanced myeloid-derived suppressor cell recruitment, pro-metastatic protein S100A8/A9
expression and metastasis burden of 4T1 breast cancer and B16F10 melanoma …
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