Background This study examined the efficacy and safety of N-acetylcysteine (NAC)
augmentation for treating irritability in children and adolescents with autism spectrum
disorders (ASD). Method Forty children and adolescents met diagnostic criteria for ASD
according to DSM-IV. They were randomly allocated into one of the two groups of NAC
(1200 mg/day)+ risperidone or placebo+ risperidone. NAC and placebo were administered
in the form of effervescent and in two divided doses for 8 weeks. Irritability subscale score of …

We established three tree-ring width chronologies from oak species in the central Zagros
Mountains, Iran, where instrumental climate data only cover a short period (1951–2010).
Due to high similarity of the individual ring-width series, we included all studied sites in a
regional chronology covering 306 years. Correlation functions with regional climate data
revealed significant positive correlations (p< 0.01) with total precipitation from previous
October to current May. Thus, we reconstructed regional precipitation variability over the …