Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

T Pietrangelo, C Puglielli, R Mancinelli… - Experimental …, 2009 - Elsevier
Sarcopenia is the age-related loss of muscle mass, strength and function. Human muscle
proteins are synthesized at a slower rate in the elderly than in young adults, leading to
atrophy and muscle mass loss with a decline in the functional capability. Additionally, aging
is accompanied by a decrease in the ability of muscle tissue to regenerate following injury or
overuse due to the impairment of intervening satellite cells, in which we previously reported
oxidative damage evidences. The aim of the present study was to determine the effects of …
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