Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4
Y Morohashi, N Hatano, S Ohya, R Takikawa… - Journal of Biological …, 2002 - ASBMB
Presenilin (PS) genes linked to early-onset familial Alzheimer's disease encode polytopic
membrane proteins that are presumed to constitute the catalytic subunit of γ-secretase,
forming a high molecular weight complex with other proteins. During our attempts to identify
binding partners of PS2, we cloned CALP (calsenilin-like protein)/KChIP4, a novel member
of calsenilin/KChIP protein family that interacts with the C-terminal region of PS. Upon co-
expression in cultured cells, CALP was directly bound to and co-localized with PS2 in …
membrane proteins that are presumed to constitute the catalytic subunit of γ-secretase,
forming a high molecular weight complex with other proteins. During our attempts to identify
binding partners of PS2, we cloned CALP (calsenilin-like protein)/KChIP4, a novel member
of calsenilin/KChIP protein family that interacts with the C-terminal region of PS. Upon co-
expression in cultured cells, CALP was directly bound to and co-localized with PS2 in …
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