Molecular cloning and characterization of UDP-glucose dehydrogenase from the amphibian Xenopus laevis and its involvement in hyaluronan synthesis
UDP-glucose dehydrogenase (UGDH) supplies the cell with UDP-glucuronic acid (UDP-
GlcUA), a precursor of glycosaminoglycan and proteoglycan synthesis. Here we reported
the cloning and the characterization of the UGDH from the amphibian Xenopus laevis that is
one of the model organisms for developmental biology. We found that X. laevis UGDH
(xUGDH) maintained a very high degree of similarity with other known UGDH sequences
both at the genomic and the protein levels. Also its kinetic parameters are similar to those of …
GlcUA), a precursor of glycosaminoglycan and proteoglycan synthesis. Here we reported
the cloning and the characterization of the UGDH from the amphibian Xenopus laevis that is
one of the model organisms for developmental biology. We found that X. laevis UGDH
(xUGDH) maintained a very high degree of similarity with other known UGDH sequences
both at the genomic and the protein levels. Also its kinetic parameters are similar to those of …
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