Molecular insights of p47phox phosphorylation dynamics in the regulation of NADPH oxidase activation and superoxide production
DN Meijles, LM Fan, BJ Howlin, JM Li - Journal of Biological Chemistry, 2014 - ASBMB
Phagocyte superoxide production by a multicomponent NADPH oxidase is important in host
defense against microbial invasion. However inappropriate NADPH oxidase activation
causes inflammation. Endothelial cells express NADPH oxidase and endothelial oxidative
stress due to prolonged NADPH oxidase activation predisposes many diseases.
Discovering the mechanism of NADPH oxidase activation is essential for developing novel
treatment of these diseases. The p47 phox is a key regulatory subunit of NADPH oxidase; …
defense against microbial invasion. However inappropriate NADPH oxidase activation
causes inflammation. Endothelial cells express NADPH oxidase and endothelial oxidative
stress due to prolonged NADPH oxidase activation predisposes many diseases.
Discovering the mechanism of NADPH oxidase activation is essential for developing novel
treatment of these diseases. The p47 phox is a key regulatory subunit of NADPH oxidase; …
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