Molecular monitoring of Plasmodium falciparum resistance to antimalarial drugs after adoption of sulfadoxine–pyrimethamine plus artesunate as the first line treatment …
M Afsharpad, S Zakeri, S Pirahmadi, ND Djadid - Acta tropica, 2012 - Elsevier
The main objective of this investigation was whether the combination therapy of sulfadoxine
pyrimethamine (SP) plus artesunate (AS) protects against the spread of resistance to SP in
malaria-endemic south-eastern Iran. Infected blood samples of Plasmodium falciparum (n=
170) were collected during 2008–2010 after the adoption of SP–AS as the first line treatment
in Iran. Four different genes of P. falciparum [dihydropteroate synthetase (pfdhps),
dihydrofolate reductase (pfdhfr), chloroquine (CQ) resistance transporter (pfcrt K76T) and …
pyrimethamine (SP) plus artesunate (AS) protects against the spread of resistance to SP in
malaria-endemic south-eastern Iran. Infected blood samples of Plasmodium falciparum (n=
170) were collected during 2008–2010 after the adoption of SP–AS as the first line treatment
in Iran. Four different genes of P. falciparum [dihydropteroate synthetase (pfdhps),
dihydrofolate reductase (pfdhfr), chloroquine (CQ) resistance transporter (pfcrt K76T) and …
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