Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis
Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of
biological understanding of the substantial clinical heterogeneity of these tumours restricts
therapeutic advances. We integrated genomic and clinicopathological analyses of a cohort
of patients with atypical teratoid rhabdoid tumours to find out the molecular basis for clinical
heterogeneity in these tumours. Methods We obtained 259 rhabdoid tumours from 37 …
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of
biological understanding of the substantial clinical heterogeneity of these tumours restricts
therapeutic advances. We integrated genomic and clinicopathological analyses of a cohort
of patients with atypical teratoid rhabdoid tumours to find out the molecular basis for clinical
heterogeneity in these tumours. Methods We obtained 259 rhabdoid tumours from 37 …
Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis
Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of
biological understanding of the substantial clinical heterogeneity of these tumours restricts
therapeutic advances. We integrated genomic and clinicopathological analyses of a cohort
of patients with atypical teratoid rhabdoid tumours to find out the molecular basis for clinical
heterogeneity in these tumours. Methods We obtained 259 rhabdoid tumours from 37 …
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of
biological understanding of the substantial clinical heterogeneity of these tumours restricts
therapeutic advances. We integrated genomic and clinicopathological analyses of a cohort
of patients with atypical teratoid rhabdoid tumours to find out the molecular basis for clinical
heterogeneity in these tumours. Methods We obtained 259 rhabdoid tumours from 37 …
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