In the present study four types of plant extracts were used to affect three gastropods in Egypt. These plantswere Calotropis procera, Pelargonium graveolens, Ethulia conyzoides and Euphorbia milii.The treatedsnails were the land snail or garden snail Eobania vermiculata and the two freshwater ones Lymnaeacaillaudi and Biomphalaria alexandrina.Traditionally, the land snails demands very high concentrations in comparison with those for thefreshwater snails. There was no effect to the extract of E. milii . The ethanol extract of E. conyzoides washighly more active than others on the snail E. vermiculata. While, the effect of E. conyzoides and E. miliion L. caillaudi and B. alexandrina were the most active according to the used concentrations. Incomparison, the extract of E. milii exhibits the highest molluscicidal activity as it caused 50% or moremortality of L. caillaudi and B. alexandrina with the least concentrations. Moreover, the mortality rate ofL. caillaudi was significantly higher than that of B. alexandrina , demonstrating a deffrential susceptibilityto the ethanol extract of E. milii.