In our case series of monkeypox (MPX) virus infected patients, one had a single genital ulcer
as the only cutaneous manifestation of the infection. Physical examination revealed a single,
rounded ulcer of the shaft penis characterized by pinkish raised, infiltrated borders and a
crusty yellowish bottom associated with bilateral inguinal lymphadenopathies. Serology for
Treponema pallidum infection and a complete screening for sexually transmitted infections
(STIs) resulted negative except for the detection of Staphylococcus aureus at the cultural …

… Dear Editor, A 46‐year‐old Italian man, considering himself a person in the category of
men who have sex with men (MSM), presented with a 6‐day history of a painless genital
tumour mimicking primary syphilis, associated with bilateral inguinal lymphadenopathy, with
absence of other systemic symptoms. After 3 days, three single umbilicated vesiculo‐pustules
appeared on penis shaft, left hand (a) and nose (b). After three additional days, the genital
nodule ruptured into a deep exuding ulcer, with selflimited progression (c). Serological tests …