cerebellum, and mutations of these channels are associated with disrupted motor function.
Several allelic variants of the α1A pore-forming subunit of P/Q-type VDCCs have been
described, and mice homozygous for these mutations exhibit gait ataxia, as do α1A knockout
mice. Here we report that heterozygous α1A mutants also have a motor phenotype. Mice
heterozygous for the leaner and α1A knockout mutations exhibit impaired motor learning in …