[HTML][HTML] MouSensor: a versatile genetic platform to create super sniffer mice for studying human odor coding
Summary Typically,∼ 0.1% of the total number of olfactory sensory neurons (OSNs) in the
main olfactory epithelium express the same odorant receptor (OR) in a singular fashion and
their axons coalesce into homotypic glomeruli in the olfactory bulb. Here, we have
dramatically increased the total number of OSNs expressing specific cloned OR coding
sequences by multimerizing a 21-bp sequence encompassing the predicted homeodomain
binding site sequence, TAATGA, known to be essential in OR gene choice. Singular gene …
main olfactory epithelium express the same odorant receptor (OR) in a singular fashion and
their axons coalesce into homotypic glomeruli in the olfactory bulb. Here, we have
dramatically increased the total number of OSNs expressing specific cloned OR coding
sequences by multimerizing a 21-bp sequence encompassing the predicted homeodomain
binding site sequence, TAATGA, known to be essential in OR gene choice. Singular gene …
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