Mouse model systems to study sex chromosome genes and behavior: relevance to humans
KH Cox, PJ Bonthuis, EF Rissman - Frontiers in neuroendocrinology, 2014 - Elsevier
Sex chromosome genes directly influence sex differences in behavior. The discovery of the
Sry gene on the Y chromosome (Gubbay et al., 1990, Koopman et al., 1990) substantiated
the sex chromosome mechanistic link to sex differences. Moreover, the pronounced
connection between X chromosome gene mutations and mental illness produces a strong
sex bias in these diseases. Yet, the dominant explanation for sex differences continues to be
the gonadal hormones. Here we review progress made on behavioral differences in mouse …
Sry gene on the Y chromosome (Gubbay et al., 1990, Koopman et al., 1990) substantiated
the sex chromosome mechanistic link to sex differences. Moreover, the pronounced
connection between X chromosome gene mutations and mental illness produces a strong
sex bias in these diseases. Yet, the dominant explanation for sex differences continues to be
the gonadal hormones. Here we review progress made on behavioral differences in mouse …
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