Multifunctional self-assembled polymeric nanoprobes for FRET-based ratiometric detection of mitochondrial H 2 O 2 in living cells
A ratiometric, multifunctional nanoprobe was prepared consisting of a self-assembled
polymeric micelle as the carrier, tetraphenylethene (TPE) as the donor, fluorescent boronate
as the H2O2-responsive acceptor, and triphenylphosphonium as a mitochondria-targeted
moiety. The assembled nanoparticles could detect both exogenous and endogenous
mitochondrial H2O2 changes in living cells.
polymeric micelle as the carrier, tetraphenylethene (TPE) as the donor, fluorescent boronate
as the H2O2-responsive acceptor, and triphenylphosphonium as a mitochondria-targeted
moiety. The assembled nanoparticles could detect both exogenous and endogenous
mitochondrial H2O2 changes in living cells.
A ratiometric, multifunctional nanoprobe was prepared consisting of a self-assembled polymeric micelle as the carrier, tetraphenylethene (TPE) as the donor, fluorescent boronate as the H2O2-responsive acceptor, and triphenylphosphonium as a mitochondria-targeted moiety. The assembled nanoparticles could detect both exogenous and endogenous mitochondrial H2O2 changes in living cells.
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