Multiple genome alignment in the telomere-to-telomere assembly era

B Kille, A Balaji, FJ Sedlazeck, M Nute, TJ Treangen - Genome Biology, 2022 - Springer
Genome Biology, 2022Springer
With the arrival of telomere-to-telomere (T2T) assemblies of the human genome comes the
computational challenge of efficiently and accurately constructing multiple genome
alignments at an unprecedented scale. By identifying nucleotides across genomes which
share a common ancestor, multiple genome alignments commonly serve as the bedrock for
comparative genomics studies. In this review, we provide an overview of the algorithmic
template that most multiple genome alignment methods follow. We also discuss prospective …
Abstract
With the arrival of telomere-to-telomere (T2T) assemblies of the human genome comes the computational challenge of efficiently and accurately constructing multiple genome alignments at an unprecedented scale. By identifying nucleotides across genomes which share a common ancestor, multiple genome alignments commonly serve as the bedrock for comparative genomics studies. In this review, we provide an overview of the algorithmic template that most multiple genome alignment methods follow. We also discuss prospective areas of improvement of multiple genome alignment for keeping up with continuously arriving high-quality T2T assembled genomes and for unlocking clinically-relevant insights.
Springer
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