Simple Summary The extracellular-signal-regulated kinase 2 (ERK2) plays a key role in the
Ras-Raf-MEK-ERK signal transduction cascade and is involved in the regulation of many
cellular processes. The ERK2 signaling converts extracellular stimuli into cell proliferation
and, when deregulated, can promote oncogenic transformation. The ERK2 missense
variants, carrying a single amino acid substitution in the protein sequence, have been
identified in cancer tissues. This study reports a comprehensive biochemical and …

The extracellular-signal-regulated kinase 2 (ERK2), a mitogen-activated protein kinase
(MAPK) located downstream of the Ras-Raf-MEK-ERK signal transduction cascade, is
involved in the regulation of a large variety of cellular processes. The ERK2, activated by
phosphorylation, is the principal effector of a central signaling cascade that converts
extracellular stimuli into cells. Deregulation of the ERK2 signaling pathway is related to
many human diseases, including cancer. This study reports a comprehensive biophysical …