Objective Neurodegenerative diseases are often characterized by the presence of
intracellular or extracellular protein aggregates in the central nervous system. Mutations of
TARDBP gene have been shown to cause Amyotrophic Lateral Sclerosis and have been
reported to present with clinical heterogeneity including parkinsonism. TDP-43 pathology
has been observed across a spectrum of neurodegenerative disorders, including
Alzheimer's and Parkinson's disease. Methods In this study we screened 100 sporadic and …