[HTML][HTML] Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies

AJ Greaney, TN Starr, CO Barnes, Y Weisblum… - BioRxiv, 2021 - ncbi.nlm.nih.gov
… We comprehensively mapped all mutations that escape binding by … antibodies targeting
the SARS-CoV-2 RBD, and compared these escape maps to those for convalescent polyclonal

[HTML][HTML] Could mutations of SARS-CoV-2 suppress diagnostic detection?

CA Ascoli - Nature biotechnology, 2021 - nature.com
… of SARS-CoV-2 viral proteins in biofluids (mainly lysates from … ‘Escape variant’ detection
is among the several well … polyclonal antibodies to N protein to detect SARS-CoV-2. Even …

[HTML][HTML] A detailed overview of immune escape, antibody escape, partial vaccine escape of SARS-CoV-2 and their emerging variants with escape mutations

C Chakraborty, AR Sharma, M Bhattacharya… - Frontiers in …, 2022 - frontiersin.org
immune escape strategies of SARS-CoV-2, primarily innate … The SARS-CoV-2 infection
causes the production dysregulation … the virus by polyclonal human plasma antibodies. However, …

An antibody-escape estimator for mutations to the SARS-CoV-2 receptor-binding domain

AJ Greaney, TN Starr, JD Bloom - Virus evolution, 2022 - academic.oup.com
… viral variants with mutations that reduce neutralization by polyclonal antibodies elicited by
vaccination or infection. … by largely distinct sets of mutations: LY-CoV016 is most strongly …

[HTML][HTML] Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

AJ Greaney, TN Starr, CO Barnes, Y Weisblum… - Nature …, 2021 - nature.com
… activity of polyclonal antibody response to SARS-CoV-2 infection is due to antibodies that …
functional effects of RBD mutations to largely predict which escape mutations will arise when …

[HTML][HTML] SARS-CoV-2 variants, spike mutations and immune escape

WT Harvey, AM Carabelli, B Jackson… - Nature Reviews …, 2021 - nature.com
… neutralization by polyclonal antibodies of the kind SARS-CoV-2 encounters in infections, with
… This lineage has spread widely in Europe and is reported to have originated in Spain 52 . …

Neutralising antibody escape of SARSCoV2 spike protein: risk assessment for antibody‐based Covid‐19 therapeutics and vaccines

D Focosi, F Maggi - Reviews in medical virology, 2021 - Wiley Online Library
… than 400,000 full SARS-CoV-2 proteome sequences (mostly from … that Spike protein mutations
in novel SARS-CoV-2 ‘variants of … DMS was also applied to polyclonal antibodies in CCP. …

[HTML][HTML] The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes

AJ Greaney, RT Eguia, TN Starr, K Khan… - PLoS …, 2022 - journals.plos.org
… We use deep mutational scanning to show that mutations to the … variant infection elicits a
polyclonal antibody response most … , we mapped antibody-binding escape mutations using the …

[HTML][HTML] A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

AJ Greaney, TN Starr, RT Eguia, AN Loes… - PLoS …, 2022 - journals.plos.org
… by these antibodies is notably less affected by mutations at … affect which mutations are
identified as antibody-escape variants. … essentially as described in [70], using a codon-optimized …

[HTML][HTML] Immune evasion of SARS-CoV-2 emerging variants: what have we learnt so far?

I Lazarevic, V Pravica, D Miljanovic, M Cupic - Viruses, 2021 - mdpi.com
… specific mainly to the spike glycoprotein, all of its parts … of antibody mixtures with non-overlapping
escape mutations should help … Polyclonal sera also contain non-neutralizing antibodies