N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following …
SS Karuppagounder, L Alin, Y Chen… - Annals of …, 2018 - Wiley Online Library
Objectives N‐acetylcysteine (NAC) is a clinically approved thiol‐containing redox
modulatory compound currently in trials for many neurological and psychiatric disorders.
Although generically labeled as an “antioxidant,” poor understanding of its site (s) of action
is a barrier to its use in neurological practice. Here, we examined the efficacy and
mechanism of action of NAC in rodent models of hemorrhagic stroke. Methods Hemin was
used to model ferroptosis and hemorrhagic stroke in cultured neurons. Striatal infusion of …
modulatory compound currently in trials for many neurological and psychiatric disorders.
Although generically labeled as an “antioxidant,” poor understanding of its site (s) of action
is a barrier to its use in neurological practice. Here, we examined the efficacy and
mechanism of action of NAC in rodent models of hemorrhagic stroke. Methods Hemin was
used to model ferroptosis and hemorrhagic stroke in cultured neurons. Striatal infusion of …
[PDF][PDF] N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with PGE2 to inhibit ferroptosis and improve outcomes following hemorrhagic …
RR Ratan - researchgate.net
Objectives N-acetylcysteine (NAC) is a clinically approved thiol-containing redox modulatory
compound currently in trials for many neurological and psychiatric disorders. Although
generically labeled as an “antioxidant”, poor understanding of its site (s) of action is a barrier
to its use in neurological practice. Here, we examined the efficacy and mechanism of action
of NAC in rodent models of hemorrhagic stroke.
compound currently in trials for many neurological and psychiatric disorders. Although
generically labeled as an “antioxidant”, poor understanding of its site (s) of action is a barrier
to its use in neurological practice. Here, we examined the efficacy and mechanism of action
of NAC in rodent models of hemorrhagic stroke.