N-terminal phosphorylation of glutaminase C decreases its enzymatic activity and cancer cell migration
CFR Ascenção, RSK Nagampalli, Z Islam, MP Pinheiro… - Biochimie, 2018 - Elsevier
The mitochondrial phosphate-activated glutaminase C (GAC) is produced by the alternative
splicing of the GLS gene. Compared to the other GLS isoform, the kidney-type glutaminase
(KGA), GAC is more enzymatically efficient and of particular importance for cancer cell
growth. Although its catalytic mechanism is well understood, little is known about how post-
translational modifications can impact GAC function. Here, we identified by mass
spectrometry a phosphorylated serine at the GLS N-terminal domain (at position 95) and …
splicing of the GLS gene. Compared to the other GLS isoform, the kidney-type glutaminase
(KGA), GAC is more enzymatically efficient and of particular importance for cancer cell
growth. Although its catalytic mechanism is well understood, little is known about how post-
translational modifications can impact GAC function. Here, we identified by mass
spectrometry a phosphorylated serine at the GLS N-terminal domain (at position 95) and …
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