NOX3, a superoxide-generating NADPH oxidase of the inner ear
B Bánfi, B Malgrange, J Knisz, K Steger… - Journal of Biological …, 2004 - ASBMB
Reactive oxygen species (ROS) play a major role in drug-, noise-, and age-dependent
hearing loss, but the source of ROS in the inner ear remains largely unknown. Herein, we
demonstrate that NADPH oxidase (NOX) 3, a member of the NOX/dual domain oxidase
family of NADPH oxidases, is highly expressed in specific portions of the inner ear. As
assessed by real-time PCR, NOX3 mRNA expression in the inner ear is at least 50-fold
higher than in any other tissues where its expression has been observed (eg fetal kidney …
hearing loss, but the source of ROS in the inner ear remains largely unknown. Herein, we
demonstrate that NADPH oxidase (NOX) 3, a member of the NOX/dual domain oxidase
family of NADPH oxidases, is highly expressed in specific portions of the inner ear. As
assessed by real-time PCR, NOX3 mRNA expression in the inner ear is at least 50-fold
higher than in any other tissues where its expression has been observed (eg fetal kidney …
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