Nanobubble extravasation in prostate tumors imaged with ultrasound: role of active versus passive targeting
R Perera, X Wang, G Ramamurtri… - 2018 IEEE …, 2018 - ieeexplore.ieee.org
Microbubble-enhanced ultrasound (US) has shown promise in detection of prostate cancer
(PCa), but sensitivity and specificity of detection remains under 65%. Development of a more
effective contrast agent for enhanced delineation of PCa with US could provide significant
improvement in this area. Targeted nano-sized US contrast agents with improved capability
to extravasate and accumulate in tumors may result in prolonged signal enhancement and
improved detection of PCa with US. We have developed a long-circulating nanobubble (NB) …
(PCa), but sensitivity and specificity of detection remains under 65%. Development of a more
effective contrast agent for enhanced delineation of PCa with US could provide significant
improvement in this area. Targeted nano-sized US contrast agents with improved capability
to extravasate and accumulate in tumors may result in prolonged signal enhancement and
improved detection of PCa with US. We have developed a long-circulating nanobubble (NB) …
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