Nanoemulsion Increases the Antifungal Activity of Amphotericin B against Four Candida auris Clades: In Vitro and In Vivo Assays
Candida auris is an emerging yeast of worldwide interest due to its antifungal resistance and
mortality rates. The aim of this study was to analyse the in vitro and in vivo antifungal activity
of a nanoemulsion loaded with amphotericin B (NEA) against planktonic cells and biofilm of
C. auris clinical isolates belonging to four different clades. In vivo assays were performed
using the Galleria mellonella model to analyse antifungal activity and histopathological
changes. The in vitro results showed that NEA exhibited better antifungal activity than free …
mortality rates. The aim of this study was to analyse the in vitro and in vivo antifungal activity
of a nanoemulsion loaded with amphotericin B (NEA) against planktonic cells and biofilm of
C. auris clinical isolates belonging to four different clades. In vivo assays were performed
using the Galleria mellonella model to analyse antifungal activity and histopathological
changes. The in vitro results showed that NEA exhibited better antifungal activity than free …
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