The use of nanotechnology in the textile industry has increased rapidly due to its unique and valuable properties. Electrospinning is a novel process for producing superfine nanofibers. Special properties make them suitable for a wide range of applications from medical to consumer products and industrial to high-tech applications. This paper details the different nanofiber manufacturing methods and its pro and cons. Further it explores the different principles of drug delivery and the application of nanofiber in pharmaceutical Drug Delivery System (DDS).