Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are
required for fear-induced suppression of feeding, but the role of endogenous LC-NE activity
in natural, homeostatic feeding remains unclear. Here, we found that LC-NE activity was
suppressed during food consumption, and the magnitude of this neural response was
attenuated as mice consumed more pellets throughout the session, suggesting that LC
responses to food are modulated by satiety state. Visual-evoked LC-NE activity was also …