Natural proteins involved in antiphospholipid syndrome
PG de Groot, B de Laat, J Rand… - … Research Highlights and …, 2017 - Springer
Antiphospholipid Syndrome: Current Research Highlights and Clinical Insights, 2017•Springer
Antiphospholipid antibodies are directed against plasma proteins with affinity for anionic
phospholipids. Autoantibodies against many plasma proteins have been described; this
chapter reviews the evidence that these plasma proteins, eg β 2-glycoprotein I, play a role in
the clinical manifestations of antiphospholipid syndrome (APS). Moreover, the chapter
discusses why these proteins become prothrombotic when the autoantibodies are present.
phospholipids. Autoantibodies against many plasma proteins have been described; this
chapter reviews the evidence that these plasma proteins, eg β 2-glycoprotein I, play a role in
the clinical manifestations of antiphospholipid syndrome (APS). Moreover, the chapter
discusses why these proteins become prothrombotic when the autoantibodies are present.
Abstract
Antiphospholipid antibodies are directed against plasma proteins with affinity for anionic phospholipids. Autoantibodies against many plasma proteins have been described; this chapter reviews the evidence that these plasma proteins, e.g. β2-glycoprotein I, play a role in the clinical manifestations of antiphospholipid syndrome (APS). Moreover, the chapter discusses why these proteins become prothrombotic when the autoantibodies are present.
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