Although naturally occurring cyclobutanes have been known for a century, until a few
decades ago nearly all were limited to a some hydrocarbons such as α-and β-pinene,
caryophyllene, or simple derivatives of these. However, with the development of more
sophisticated analytical and spectroscopic techniques, the isolation and structural
characterization of new compounds have resulted in a large growth of known cyclobutane
derivatives both simple ones and some being rather complex having the cyclobutane moiety …