Nature of β-1, 3-glucan-exposing features on Candida albicans cell wall and their modulation
Candida albicans exists as a commensal of mucosal surfaces and the gastrointestinal tract
without causing pathology. However, this fungus is also a common cause of mucosal and
systemic infections when antifungal immune defenses become compromised. The activation
of antifungal host defenses depends on the recognition of fungal pathogen-associated
molecular patterns (PAMPs), such as β-1, 3-glucan. In C. albicans, most β-1, 3-glucan is
present in the inner cell wall, concealed by the outer mannan layer, but some β-1, 3-glucan …
without causing pathology. However, this fungus is also a common cause of mucosal and
systemic infections when antifungal immune defenses become compromised. The activation
of antifungal host defenses depends on the recognition of fungal pathogen-associated
molecular patterns (PAMPs), such as β-1, 3-glucan. In C. albicans, most β-1, 3-glucan is
present in the inner cell wall, concealed by the outer mannan layer, but some β-1, 3-glucan …
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