Neonatal Candida auris infection: Management and prevention strategies – A single centre experience
J Chandramati, L Sadanandan, A Kumar… - … of Paediatrics and …, 2020 - Wiley Online Library
J Chandramati, L Sadanandan, A Kumar, S Ponthenkandath
Journal of Paediatrics and Child Health, 2020•Wiley Online LibraryAim Our aim was to identify the clinical features and outcome of multidrug resistant Candida
auris (CA) infection in neonates. Methods This is a retrospective case cohort study of 17
neonates who developed sepsis caused by CA infection in a tertiary care neonatal intensive
care unit over 3 years. The risk factors, clinical features, treatment and outcome were
studied. Results The mean gestation was 32.4±4.9 weeks with overall mortality of 41%.
Clinical features were indistinguishable from other causes of sepsis. CA was sensitive to …
auris (CA) infection in neonates. Methods This is a retrospective case cohort study of 17
neonates who developed sepsis caused by CA infection in a tertiary care neonatal intensive
care unit over 3 years. The risk factors, clinical features, treatment and outcome were
studied. Results The mean gestation was 32.4±4.9 weeks with overall mortality of 41%.
Clinical features were indistinguishable from other causes of sepsis. CA was sensitive to …
Aim
Our aim was to identify the clinical features and outcome of multidrug resistant Candida auris (CA) infection in neonates.
Methods
This is a retrospective case cohort study of 17 neonates who developed sepsis caused by CA infection in a tertiary care neonatal intensive care unit over 3 years. The risk factors, clinical features, treatment and outcome were studied.
Results
The mean gestation was 32.4 ± 4.9 weeks with overall mortality of 41%. Clinical features were indistinguishable from other causes of sepsis. CA was sensitive to micafungin but resistant to fluconazole and had variable sensitivity to voriconazole and amphotericin. Survival improved to 83% when infants were treated with a combination of micafungin and amphotericin. Non‐survivors were of lower birthweights and had other risk factors.
Conclusions
The management guidelines and infection control measures are described in this largest series of neonatal CA infection. Treatment with a combination of amphotericin and micafungin improved the outcome.
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