Background Family history of depression is a robust predictor of early-onset depression,
which may confer risk through alterations in neural circuits that have been implicated in
reward and emotional processing. These alterations may be evident in youths who are at
familial risk for depression but who do not currently have depression. However, the
identification of robust and replicable findings has been hindered by few studies and small
sample sizes. In the current study, we sought to identify functional connectivity (FC) patterns …