Neural network modelling reveals changes in directional connectivity between cortical and hypothalamic regions with increased BMI
Abstract Background/Objectives Obesity has been ascribed to corticostriatal regions taking
control over homeostatic areas. To test this assumption, we applied an effective connectivity
approach to reveal the direction of information flow between brain regions and the valence
of connections (excitatory versus inhibitory) as a function of increased BMI and homeostatic
state. Subjects/Methods Forty-one participants (21 overweight/obese) underwent two resting-
state fMRI scans: after overnight fasting (hunger) and following a standardised meal …
control over homeostatic areas. To test this assumption, we applied an effective connectivity
approach to reveal the direction of information flow between brain regions and the valence
of connections (excitatory versus inhibitory) as a function of increased BMI and homeostatic
state. Subjects/Methods Forty-one participants (21 overweight/obese) underwent two resting-
state fMRI scans: after overnight fasting (hunger) and following a standardised meal …
Neural network modelling reveals changes in directional connectivity between cortical and hypothalamic regions in obesity
Obesity has been ascribed to corticostriatal regions taking control over homeostatic areas.
To test this assumption, we applied an effective connectivity approach to reveal the direction
of information flow between brain regions and the valence of connections (excitatory versus
inhibitory) as a function of adiposity and homeostatic state. Forty-one participants (21
overweight/obese) underwent two resting-state fMRI scans: after overnight fasting (hunger)
and following a standardised meal (satiety). We used spectral dynamic causal modelling to …
To test this assumption, we applied an effective connectivity approach to reveal the direction
of information flow between brain regions and the valence of connections (excitatory versus
inhibitory) as a function of adiposity and homeostatic state. Forty-one participants (21
overweight/obese) underwent two resting-state fMRI scans: after overnight fasting (hunger)
and following a standardised meal (satiety). We used spectral dynamic causal modelling to …