infants, has both endogenous and exogenous components. One of the endogenous
components is the paucity of developmentally regulated protectors. Here we expand on this
component, discussing the potential roles of one putative protector, neuregulin (NRG)-1, in
brain development and damage. We outline how NRG-1 might be involved in perinatal brain
damage pathomechanisms and suggest that NRG-1 might be one target for intervention.