Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state
CJ Pike, D Burdick, AJ Walencewicz… - Journal of …, 1993 - Soc Neuroscience
The progressive neurodegeneration of Alzheimer's disease has been hypothesized to be
mediated, at least in part, by beta-amyloid protein. A relationship between the aggregation
state of beta-amyloid protein and its ability to promote degeneration in vitro has been
previously suggested. To evaluate this hypothesis and to define a structure-activity
relationship for beta-amyloid, aggregation properties of an overlapping series of synthetic
beta-amyloid peptides (beta APs) were investigated and compared with beta AP neurotoxic …
mediated, at least in part, by beta-amyloid protein. A relationship between the aggregation
state of beta-amyloid protein and its ability to promote degeneration in vitro has been
previously suggested. To evaluate this hypothesis and to define a structure-activity
relationship for beta-amyloid, aggregation properties of an overlapping series of synthetic
beta-amyloid peptides (beta APs) were investigated and compared with beta AP neurotoxic …
[引用][C] Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state
P CJ - J Neurosci, 1993 - cir.nii.ac.jp
Neurodegeneration induced by beta-amyloid peptides in vitro : the role of peptide assembly
state | CiNii Research … Neurodegeneration induced by beta-amyloid peptides in vitro : the
role of peptide assembly state …
state | CiNii Research … Neurodegeneration induced by beta-amyloid peptides in vitro : the
role of peptide assembly state …