Salvia divinorum is a perennial sage native to Oaxaca, Mexico, that has been used
traditionally in divination rituals and as a treatment for the “semimagical” disease panzón de
borrego. Because of the intense “out-of-body” experiences reported after inhalation of the
pyrolized smoke, S. divinorum has been gaining popularity as a recreational hallucinogen,
and the United States and several other countries have regulated its use. Early studies
isolated the neoclerodane diterpene salvinorin A as the principal psychoactive constituent …