Background Opioid misuse is hypothesized to compromise the ability to regulate negative
emotions, as manifested through visceral and peripheral physiological signals. However,
neurophysiological impairment of top-down cognitive emotion regulation in opioid misuse
has not previously been shown. Methods Patients with chronic pain who had been taking
opioids for 90 days or longer (N= 149; female, n= 98) underwent a negative emotion
regulation task with electroencephalography. Participants were instructed to view or …