Dietary interventions have been proposed as a way to increase lifespan and improve health.
The senescence-accelerated prone 8 (SAMP8) mice have a shorter lifespan and show
alterations in the central nervous system. Moreover, this mouse strain shows decreased
sirtuin 1 protein expression and elevated expression of the acetylated targets NFκB and
FoxO1, which are implicated in transcriptional control of key genes in cell proliferation and
cell survival, in reference to control strain, SAMR1. After eight weeks of intermittent fasting …