New LPA1 receptor modulators: Design, synthesis, in-silico, and anticancer studies of triazole and oxadiazole analogs
Lysophosphatidic acid (LPA) is a bioactive signaling molecule that activates LPA 1
receptors, which are over expressed in breast cancer. This signaling cascade promotes
cancer cell proliferation, survival, metastasis, and angiogenesis. Small molecules that block
LPA 1 signaling could benefit breast cancer therapy. Novel 1, 2, 4-triazoles and 1, 3, 4-
oxadiazoles conjugates of benzimidazole/oxazole/thiazole were designed as LPA 1
receptor inhibitors, synthesized, and the in-vitro anticancer activity was examined through …
receptors, which are over expressed in breast cancer. This signaling cascade promotes
cancer cell proliferation, survival, metastasis, and angiogenesis. Small molecules that block
LPA 1 signaling could benefit breast cancer therapy. Novel 1, 2, 4-triazoles and 1, 3, 4-
oxadiazoles conjugates of benzimidazole/oxazole/thiazole were designed as LPA 1
receptor inhibitors, synthesized, and the in-vitro anticancer activity was examined through …
以上显示的是最相近的搜索结果。 查看全部搜索结果